Complement in Metastasis: A Comp in the Camp

Frontiers in Immunology

Ruben Pio²  Sergio Ortiz-Espinosa²  Daniel Ajona²  Fernando Lecanda³ 

[1] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain;Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain;Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain;Navarra Institute for Health Research (IdISNA), Pamplona, Spain;Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain;

关键词: cancer;    metastasis;    complement;    tumor microenvironment;    anaphylatoxin;    bone colonization;   

DOI  :  10.3389/fimmu.2019.00669

来源: DOAJ

【 摘 要 】

The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d'horizon on recent advances in this area and their prospective potential for cancer treatment.

【 授权许可】

Unknown