Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

Coatings

Giuseppe Cavallaro¹  Filippo Parisi¹  Stefana Milioto¹  Lorenzo Lisuzzo¹  Giuseppe Lazzara¹  Rawil Fakhrullin² 

[1] Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, pad. 17, 90128 Palermo, Italy;Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan 420008, Russia;

关键词: halloysite;    alginate;    chitosan;    gel beads;    drug release;   

DOI  :  10.3390/coatings9020070

来源: DOAJ

【 摘 要 】

The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.

【 授权许可】

Unknown