Numerical study on propagation mechanism and bio-medicine applications of plasma jet

High Voltage

Dawei Liu¹  He Cheng¹  Xin Liu¹  Xinpei Lu¹ 

[1] Huazhong University of Science and Technology;

关键词: biomembranes;    biomolecular effects of radiation;    cellular effects of radiation;    electron density;    electron impact dissociation;    enzymes;    ignition;    microorganisms;    numerical analysis;    Penning discharges;    Penning ionisation;    plasma chemistry;    plasma density;    plasma jets;    plasma sheaths;    plasma sources;    water;    plasma jet propagation mechanism;    biomedical applications;    two-dimensional numerical model;    plasma sheath formation;    plasma channel;    dielectric tube;    photoionisation;    air species;    localised discharge-to-streamer transition;    Penning ionisation;    electric conductivity;    ring-shaped plasma bullet formation;    electron-impact dissociation;    electron neutralisation;    water dissociation;    plasma reactions;    ignition voltage;    pre-avalanche electron density;    plasma treatment simulation;    bacteria biofilm;    cell membrane;    cytosolic fumarase B;    H(2)O;   

DOI  :  10.1049/hve.2016.0023

来源: DOAJ

【 摘 要 】

In this study, the propagation mechanism of plasma jet and some bio-medical applications are investigated by two-dimensional numerical model. The key equations of plasma physics and chemistry related with plasma jet are firstly introduced. The simulation results suggest that the sheath forms near the dielectric tube inner surface, which results in the plasma channel to shrink in the radial direction inside the dielectric tube. The photoionisation of air species plays a crucial role in the transition from the localised discharge to streamer. The Penning ionisation increases the electric conductivity of the plasma channel and facilitates the formation of ring-shaped plasma bullet. For the plasma jet in the open air, electron-impact dissociation of H(2)O, electron neutralisation of H(2)O^+, as well as dissociation of H(2)O by O(1D) are found to be the main reactions to produce OH. For micro plasma jet, the higher ignition voltage as the tube diameter decreased is attributed to the deceasing pre-avalanche electron density inside the tube. The simulation of plasma treatment of bacteria biofilm indicates that the mean free path of charged species in µm scale permitted the plasma penetrate into the cavity of the biofilm, and the structure of the biofilm results in the non-uniform distribution of ROS and RNS. The simulation of plasma treatment of cells immersed in liquid suggests that the HO(2) generated by plasma aqueous species is the only way for superoxide to penetrate cell membrane and damage cytosolic fumarase B.

【 授权许可】

Unknown