Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases

Frontiers in Aging Neuroscience

Jialin C. Zheng²  Diksha Basnet³  Jianhui Liu³  Yiyan Sun³  Jian Huang⁴  Xiaohuan Xia⁶ 

[1] Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China;Department of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China;Shanghai Frontiers Science Center of Nanocatalytic Medicine, Shanghai, China;Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;

关键词: ferroptosis;    neurodegenerative diseases;    iron metabolism;    oxidative stress;    redox regulation;   

DOI  :  10.3389/fnagi.2022.904152

来源: DOAJ

【 摘 要 】

Neurodegenerative diseases are a diverse class of diseases attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and multiple sclerosis. The pathogenesis of neurodegenerative diseases is complex and diverse, often involving mitochondrial dysfunction, neuroinflammation, and epigenetic changes. However, the pathogenesis of neurodegenerative diseases has not been fully elucidated. Recently, accumulating evidence revealed that ferroptosis, a newly discovered iron-dependent and lipid peroxidation-driven type of programmed cell death, provides another explanation for the occurrence and progression of neurodegenerative diseases. Here, we provide an overview of the process and regulation mechanisms of ferroptosis, and summarize current research progresses that support the contribution of ferroptosis to the pathogenesis of neurodegenerative diseases. A comprehensive understanding of the emerging roles of ferroptosis in neurodegenerative diseases will shed light on the development of novel therapeutic technologies and strategies for slowing down the progression of these diseases.

【 授权许可】

Unknown