Animal Models of Interferon Signature Positive Lupus

Frontiers in Immunology

Haoyang eZhuang¹  Shuhong eHan¹  Christopher eSzeto¹  Lijun eYang¹  Westley H. Reeves¹ 

[1] University of Florida;

关键词: Apoptosis;    Lupus Erythematosus, Systemic;    Toll-Like Receptors;    Animal Models;    B cell activation;    interferon alpha;   

DOI  :  10.3389/fimmu.2015.00291

来源: DOAJ

【 摘 要 】

Human lupus is strongly associated with a gene expression signature characterized by over-expression of type I interferon-regulated genes.A strong interferon signature is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor (TLR)-driven interferon production.In contrast, pristane-induced lupus exhibits a prominent TLR7-dependent interferon signature.Importantly, genetic disorders with dysregulated interferon production in both humans and mice cause severe autoinflammatory diseases but not the typical manifestations of lupus suggesting that interferon over-production by itself is insufficient to cause SLE.Murine single-gene models suggest that lupus-like disease may result from abnormalities in B cell activation and the clearance of dead cells.Pristane may mimic human SLE by causing interferon production along with synergistic abnormalities affecting clearance of apoptotic cells and activation of B cell signaling.

【 授权许可】

Unknown