Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

Breast

Yong Bae Kim¹  Su Ssan Kim²  Sung Ja Ahn³  Tae Hyun Kim⁴  Jee Suk Chang⁵  Hae Jin Park⁶  Doo Ho Choi⁷  Jin-Hwa Choi⁸  Won Park⁹  Haeyoung Kim⁹  Jin Hee Kim^1,10 

[1] Corresponding author. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.;Corresponding author. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 06351, South Korea.;Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;Chonnam National University Medical School, Gwangju, South Korea;Chung-Ang University Hospital, China;Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea;Hanyang University College of Medicine, Seoul, South Korea;Research Institute and Hospital, National Cancer Center, Goyang, South Korea;Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea;

关键词: Neoplasms;    Unknown primary;    Breast neoplasm;    Lymph nodes;    Magnetic resonance imaging;    Radiotherapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.

【 授权许可】

Unknown