Finding small molecules for the ‘next Ebola’ [v2; ref status: indexed, http://f1000r.es/5lb]

F1000Research

Megan Coffee¹  Sean Ekins²  Christopher Southan³ 

[1] Center for Infectious Diseases and Emergency Readiness, University of California at Berkeley, 1918 University Ave, Berkeley, CA, 94704, USA;Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, USA;IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, UK;

关键词: Antimicrobials & Drug Resistance;    Drug Discovery & Design;    Tropical & Travel-Associated Diseases;    Virology;   

DOI  :  10.12688/f1000research.6181.2

来源: DOAJ

【 摘 要 】

The current Ebola virus epidemic may provide some suggestions of how we can better prepare for the next pathogen outbreak. We propose several cost effective steps that could be taken that would impact the discovery and use of small molecule therapeutics including: 1. text mine the literature, 2. patent assignees and/or inventors should openly declare their relevant filings, 3. reagents and assays could be commoditized, 4. using manual curation to enhance database links, 5. engage database and curation teams, 6. consider open science approaches, 7. adapt the “box” model for shareable reference compounds, and 8. involve the physician’s perspective.

【 授权许可】

Unknown