Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α

Journal of Functional Foods

Dong-Kwon Rhee¹  Suhkneung Pyo²  Byung-Oh Kim³  Hee-Weon Lee⁴  Chung Gi Lee⁴ 

[1] Biotechnology, College of Agriculture &Life Sciences, Kyungpook National University, Daegu, Republic of Korea;;School of Food Science &School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea;

关键词: Allicin;    Invasion;    Metastasis;    VCAM-1;    ER-α;   

DOI  :  

来源: DOAJ

【 摘 要 】

Allicin, one of the major components of garlic, has wide-ranging health properties. However, the effects of allicin on migration and invasion of breast cancer cells remain unknown. Allicin (0.1–10 ng/ml) inhibited TNF-α-induced VCAM-1 protein expression in MCF-7, but not in MDA-MB-231. Additionally, allicin significantly reduced tumor cell migration and invasion only in MCF-7 cells. Our results also demonstrated that protein interaction between ER-α and p65 was down-regulated by TNF-α treatment, and this effect was reversed by allicin. Moreover, the inhibition of ER-α expression markedly enhanced TNF-α-induced migration and invasion of MCF-7 cells. Allicin strongly suppressed TNF-α-induced activation of ERK1/2. Collectively, these results suggest that allicin inhibited the TNF-α-mediated induction of VCAM-1 through blocking ERK1/2 and NF-κB signaling pathways and enhancing interaction between ER-α and p65, leading to the suppression of invasion and metastasis of MCF-7 cells. Therefore, allicin could be useful for preventing the advancement of breast cancer.

【 授权许可】

Unknown