Tumor Necrosis Factor-α Variations in Patients With Major Depressive Disorder Before and After Antidepressant Treatment

Frontiers in Psychiatry

JiJun Wang²  Wei Sun³  YanYan Wei⁴  Li Hui⁴  LiangHu Chen⁵  LiHong Pan⁵  ChunHong Gu⁵  Lin Yao⁵  Min Qian⁵  TianHong Zhang⁶  LiHua Xu⁶  XiaoChen Tang⁶  YeGang Hu⁶  XiaoHua Liu⁶ 

[1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai, China;Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China;Department of Neurosurgery, Pu Nan Hospital, Shanghai, China;Institute of Mental Health, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Soochow University, Shanghai, China;Nanhui Mental Health Center, Pudong New Area, Shanghai, China;Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China;

关键词: remission;    serum;    antidepressant;    major depressive disorder;    tumor necrosis factor-α;   

DOI  :  10.3389/fpsyt.2020.518837

来源: DOAJ

【 摘 要 】

Tumor necrosis factor-α (TNF-α) had been identified as a key pro-inflammatory cytokine in the pathophysiology of major depressive disorder (MDD) and the mechanism of antidepressant treatment. The primary aim of the present study was to examine the serum TNF-α levels in Chinese inpatients with MDD during the acute phase and to explore the changes in TNF-α levels after effective clinical treatment. Fifty-seven consecutive inpatients with MDD and 30 healthy controls were recruited. The serum TNF-α levels were detected using ELISA. Symptoms of depression were evaluated using the 24-item Hamilton Rating Scale for Depression (HAM-D-24). TNF-α levels and HAM-D-24 scores were assessed at baseline and after 2 and 12 weeks of follow-up. The serum TNF-α levels were higher in the MDD group than in the control group. After 2 and 12 weeks of antidepressant treatment, there were significant improvements in the patients' symptoms and significant decreases in the TNF-α levels. The baseline TNF-α levels significantly correlated with the decreased HAM-D-24 scores, particularly for the depressive symptoms of anxiety/somatization and weight loss. The present findings indicate that depression is accompanied by activation of TNF-α, which also has a predictive value for the antidepressant treatment response in patients with MDD.

【 授权许可】

Unknown