Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Brain Stimulation

Jerome J. Maller, BSc, GradDipPsych, MSc, PhD¹  Kate E. Hoy, BBNSc (Hons), DPsych (Clin Neuro)²  Richard Thomson, BEng (Hons), PhD²  Zafiris J. Daskalakis, MD, FRCP(C)²  Paul B. Fitzgerald, MBBS, MPM, PhD, FRANZCP² 

[1] Correspondence: Professor Paul B. Fitzgerald, Alfred Psychiatry Research Centre, First Floor, Old Baker Building, The Alfred, Commercial Rd Melbourne, Victoria, Australia, 3004.;Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Victoria, Australia;

关键词: repetitive transcranial magnetic stimulation;    depression;    prefrontal cortex;    response;    remission;    antidepressant;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.

【 授权许可】

Unknown