The Life-Cycle of the HIV-1 Gag–RNA Complex

Viruses

Serena Bernacchi¹  Elodie Mailler¹  Valérie Vivet-Boudou¹  Redmond P. Smyth¹  Roland Marquet¹  Jean-Christophe Paillart¹ 

[1] Architecture et Réactivité de l’ARN, Université de Strasbourg, IBMC, CNRS, 15 rue René Descartes, 67084 Strasbourg, France;

关键词: HIV-1;    packaging;    Gag;    genomic RNA;    assembly;   

DOI  :  10.3390/v8090248

来源: DOAJ

【 摘 要 】

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55Gag precursor polyprotein, and the processes leading to its incorporation into viral particles.

【 授权许可】

Unknown