eLife | |
Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria | |
Hiroko Okada1  Tomoyo Taniguchi2  Kazutomo Suzue2  Takashi Imai2  Chikako Shimokawa2  Hajime Hisaeda3  Hidekazu Ishida4  | |
[1] Center for Medical Education, Gunma University Faculty of Medicine, Maebashi, Japan;Department of Parasitology, Gunma University Graduate School of Medicine, Maebashi, Japan;Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Science, Yokohama, Japan;Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan; | |
关键词: malaria; erythroblast; CD8+ T cell; | |
DOI : 10.7554/eLife.04232 | |
来源: DOAJ |
【 摘 要 】
The protective immunity afforded by CD8+ T cells against blood-stage malaria remains controversial because no MHC class I molecules are displayed on parasite-infected human erythrocytes. We recently reported that rodent malaria parasites infect erythroblasts that express major histocompatibility complex (MHC) class I antigens, which are recognized by CD8+ T cells. In this study, we demonstrate that the cytotoxic activity of CD8+ T cells contributes to the protection of mice against blood-stage malaria in a Fas ligand (FasL)-dependent manner. Erythroblasts infected with malarial parasites express the death receptor Fas. CD8+ T cells induce the externalization of phosphatidylserine (PS) on the infected erythroblasts in a cell-to-cell contact-dependent manner. PS enhances the engulfment of the infected erythroid cells by phagocytes. As a PS receptor, T-cell immunoglobulin-domain and mucin-domain-containing molecule 4 (Tim-4) contributes to the phagocytosis of malaria-parasite-infected cells. Our findings provide insight into the molecular mechanisms underlying the protective immunity exerted by CD8+ T cells in collaboration with phagocytes.
【 授权许可】
Unknown