Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria

eLife

Hiroko Okada¹  Tomoyo Taniguchi²  Kazutomo Suzue²  Takashi Imai²  Chikako Shimokawa²  Hajime Hisaeda³  Hidekazu Ishida⁴ 

[1] Center for Medical Education, Gunma University Faculty of Medicine, Maebashi, Japan;Department of Parasitology, Gunma University Graduate School of Medicine, Maebashi, Japan;Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Science, Yokohama, Japan;Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan;

关键词: malaria;    erythroblast;    CD8+ T cell;   

DOI  :  10.7554/eLife.04232

来源: DOAJ

【 摘 要 】

The protective immunity afforded by CD8+ T cells against blood-stage malaria remains controversial because no MHC class I molecules are displayed on parasite-infected human erythrocytes. We recently reported that rodent malaria parasites infect erythroblasts that express major histocompatibility complex (MHC) class I antigens, which are recognized by CD8+ T cells. In this study, we demonstrate that the cytotoxic activity of CD8+ T cells contributes to the protection of mice against blood-stage malaria in a Fas ligand (FasL)-dependent manner. Erythroblasts infected with malarial parasites express the death receptor Fas. CD8+ T cells induce the externalization of phosphatidylserine (PS) on the infected erythroblasts in a cell-to-cell contact-dependent manner. PS enhances the engulfment of the infected erythroid cells by phagocytes. As a PS receptor, T-cell immunoglobulin-domain and mucin-domain-containing molecule 4 (Tim-4) contributes to the phagocytosis of malaria-parasite-infected cells. Our findings provide insight into the molecular mechanisms underlying the protective immunity exerted by CD8+ T cells in collaboration with phagocytes.

【 授权许可】

Unknown