Memórias do Instituto Oswaldo Cruz | |
Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development | |
Sze-wah Tse1  Andrea J Radtke1  Fidel Zavala1  | |
[1] ,Johns Hopkins University Johns Hopkins Malaria Research Institute Johns Hopkins Bloomberg School of Public Health | |
关键词: malaria; CD8+ T cell; vaccine; sporozoites; | |
DOI : 10.1590/S0074-02762011000900022 | |
来源: SciELO | |
【 摘 要 】
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation of sporozoite antigen requires TAP mediated transport of major histocompatibility complex class I epitopes to the endoplasmic reticulum. Importantly, in DCs this process is also dependent on endosome-mediated cross presentation while this mechanism is not required for epitope presentation on hepatocytes. Protective CD8+ T cell responses are strongly dependent on the presence of CD4+ T cells and the capacity of sporozoite antigen to persist for a prolonged period of time. While human trials with subunit vaccines capable of inducing antibodies and CD4+ T cell responses have yielded encouraging results, an effective anti-malaria vaccine will likely require vaccine constructs designed to induce protective CD8+ T cells against malaria liver stages.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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