Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development

Memórias do Instituto Oswaldo Cruz

Sze-wah Tse¹  Andrea J Radtke¹  Fidel Zavala¹ 

[1] ,Johns Hopkins University Johns Hopkins Malaria Research Institute Johns Hopkins Bloomberg School of Public Health

关键词: malaria;    CD8+ T cell;    vaccine;    sporozoites;   

DOI  :  10.1590/S0074-02762011000900022

来源: SciELO

【 摘 要 】

CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation of sporozoite antigen requires TAP mediated transport of major histocompatibility complex class I epitopes to the endoplasmic reticulum. Importantly, in DCs this process is also dependent on endosome-mediated cross presentation while this mechanism is not required for epitope presentation on hepatocytes. Protective CD8+ T cell responses are strongly dependent on the presence of CD4+ T cells and the capacity of sporozoite antigen to persist for a prolonged period of time. While human trials with subunit vaccines capable of inducing antibodies and CD4+ T cell responses have yielded encouraging results, an effective anti-malaria vaccine will likely require vaccine constructs designed to induce protective CD8+ T cells against malaria liver stages.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License