Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder

Frontiers in Psychiatry

Gang Zhu¹  Xiaojun Shao² 

[1] Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, China;Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: personality traits;    mood disorder;    major depressive disorder;    monoamine neurotransmitters;    mechanism;   

DOI  :  10.3389/fpsyt.2020.00381

来源: DOAJ

【 摘 要 】

Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certainly multifactorial and comprehensive. Monoamine neurotransmitter system dysfunction and specific personality traits are independent risk factors for depression and suicide. These factors also demonstrate complex interactions that influence MDD pathogenesis and symptom expression. In this review, we assess these relationships with the aim of providing a reference for the development of precision medicine.

【 授权许可】

Unknown