Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders?

Cells

卷:10

Oliver Ambrée¹  Jana Freff²  Judith Alferink²  Udo Dannlowski²  BernhardT. Baune²  Rafael Leite Dantas²  EvaC. Beins³  AndreasJ. Forstner³  Stefanie Scheu⁴ 

[1] Department of Behavioural Biology, University of Osnabrück, 49076 Osnabrück, Germany;

[2] Department of Mental Health, University of Münster, 48149 Münster, Germany;

[3] Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, 53127 Bonn, Germany;

[4] Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany;

关键词: mood disorder;    bipolar disorder;    major depressive disorder;    neuroinflammation;    inflammation;    dendritic cell;   

DOI  :  10.3390/cells10040941

来源: DOAJ

【 摘 要 】

Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum levels of pro-inflammatory cytokines and neuroinflammation are common findings in patients with AD and in corresponding animal models. Dendritic cells (DCs) represent a heterogeneous population of myeloid cells that orchestrate innate and adaptive immune responses and self-tolerance. Upon sensing exogenous and endogenous danger signals, mature DCs secrete proinflammatory factors, acquire migratory and antigen presenting capacities and thus contribute to neuroinflammation in trauma, autoimmunity, and neurodegenerative diseases. However, little is known about the involvement of DCs in the pathogenesis of AD. In this review, we summarize the current knowledge on DCs in peripheral immune responses and neuroinflammation in MDD and BD. In addition, we consider the impact of DCs on neuroinflammation and behavior in animal models of AD. Finally, we will discuss therapeutic perspectives targeting DCs and their effector molecules in mood disorders.

【 授权许可】

Unknown