Development of a New Monomer for the Synthesis of Intrinsic Antimicrobial Polymers with Enhanced Material Properties

International Journal of Molecular Sciences

Sophia Dohlen¹  Carina Braun¹  Judith Kreyenschmidt¹  Martin Kreyenschmidt²  Florian Brodkorb²  Björn Fischer²  Oliver Robers²  Katrin Kalbfleisch²  Reinhard Lorenz² 

[1] Institute of Animal Science, University Bonn, Katzenburgweg 7-9, 53113 Bonn, Germany;Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany;

关键词: monomer;    antimicrobial polymer;    biocide;    intrinsic antimicrobial;   

DOI  :  10.3390/ijms160820050

来源: DOAJ

【 摘 要 】

The use of biocidal compounds in polymers is steadily increasing because it is one solution to the need for safety and hygiene. It is possible to incorporate an antimicrobial moiety to a polymer. These polymers are referred to as intrinsic antimicrobial. The biocidal action results from contact of the polymer to the microorganisms, with no release of active molecules. This is particularly important in critical fields like food technology, medicine and ventilation technology, where migration or leaching is crucial and undesirable. The isomers N-(1,1-dimethylethyl)-4-ethenyl-benzenamine and N-(1,1-dimethyl-ethyl)-3-ethenyl-benzenamine (TBAMS) are novel (Co-)Monomers for intrinsic anti-microbial polymers. The secondary amines were prepared and polymerized to the corresponding water insoluble polymer. The antimicrobial activity was analyzed by the test method JIS Z 2801:2000. Investigations revealed a high antimicrobial activity against Staphylococcus aureus and Escherichia coli with a reduction level of >4.5 log10 units. Furthermore, scanning electron microscopy (SEM) of E. coli. in contact with the polymer indicates a bactericidal action which is caused by disruption of the bacteria cell membranes, leading to lysis of the cells.

【 授权许可】

Unknown