Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

International Journal of Molecular Sciences

Jürgen Bachl¹  Judith Mayr¹  David Díaz Díaz¹  Jens Schlossmann² 

[1] Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany;Institut für Pharmazie, Pharmakologie und Toxikologie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany;

关键词: antimicrobial polymer;    ionenes;    polycations;    quaternary ammonium;    hemolysis;    topomers;   

DOI  :  10.3390/ijms18020303

来源: DOAJ

【 摘 要 】

A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.

【 授权许可】

Unknown