Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Frontiers in Immunology

Corey T. Watson¹  Amy L. Kenter²  Jan-Hendrik Spille³ 

[1] Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, United States;Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States;Department of Physics, University of Illinois at Chicago, Chicago, IL, United States;

关键词: Chromatin;    B cell;    immunoglobulin;    VDJ recombination;    VDJ repertoire;   

DOI  :  10.3389/fimmu.2021.682589

来源: DOAJ

【 摘 要 】

Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons of expressed immunoglobulins and T cell receptors. This process creates the potential for an organism to respond to large numbers of different pathogens. Here, we consider the possibility that genetic polymorphisms with alterations in a vast array of regulatory elements in the immunoglobulin heavy chain (IgH) locus lead to changes in locus topology and impact immune-repertoire formation.

【 授权许可】

Unknown