Harnessing adipogenesis to prevent obesity

Adipocyte

Louise Larose¹  Nida Haider¹ 

[1] McGill University and The Research Institute of McGill University Health Centre;

关键词: adipocyte precursor cells;    adipocyte;    adipogenesis;    white adipose tissue;    obesity;    aregs;    pdgfrα;    mirna;    lncrna;   

DOI  :  10.1080/21623945.2019.1583037

来源: DOAJ

【 摘 要 】

Obesity and associated metabolic complications, including diabetes, cardiovascular and hepatic diseases, and certain types of cancers, create a major socioeconomic burden. Obesity is characterized by excessive expansion of white adipose tissue resulting from increased adipocyte size, and enhanced adipocyte precursor cells proliferation and differentiation into mature adipocytes, a process well-defined as adipogenesis. Efforts to develop therapeutically potent strategies to circumvent obesity are impacted by our limited understanding of molecular mechanisms regulating adipogenesis. In this review, we discuss recently discovered molecular mechanisms restraining adipogenesis. In this perspective, the discoveries of white adipose tissue endogenous adipogenesis-regulatory cells (Aregs) that negatively regulate adipocyte differentiation, platelet-derived growth factor receptor isoform α (PDGFRα) activation and downstream signaling that hinder adipocyte precursors differentiation, and a group of obesity-associated non-coding RNAs (ncRNAs) that regulate adipogenesis open up promising therapeutic avenues to prevent and/or treat obesity.

【 授权许可】

Unknown