IBF-R, a botanical extract of Rhus verniciflua controls obesity in which AMPK-SIRT1 axis and ROS regulatory mechanism are involved in mice

Journal of Functional Foods

Hwa-Young Lee¹  Han-Jung Chae²  Young Yoon²  Jung-Hyun Kim³  Seon-Ah Park⁴  The-Hiep Hoang⁵  Cheng Peng⁵  Geum-Hwa Lee⁵ 

[1] Food Research Institute, Doin 2-gil, Seongsu-myeon, Imsil-gun, Jeonbuk 55918, Korea;Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea;Department of Pharmacology, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea;;Imsil Cheese &Non-Clinical Evaluation Center, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea;

关键词: Rhus verniciflua;    Obesity;    AMPK;    SIRT1;    PGC1α deacetylation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Obesity is a major health concern worldwide and adds woes to the quality of life. Several natural herbs have been shown protective effects against obesity. Here, we investigated the protective effect of Rhus verniciflua extract (IBF-R) against obesity and the underlying mechanism in obese mice. IBF-R alleviated body weight, liver weight as well as adipose tissue weight without altering food intake. IBF-R extract reduced lipogenesis and adipogenesis in liver and epididymal white adipose tissue (eWAT). At the molecular level, AMPK-SIRT1 axis increased, and mTOR-SREBP1-ER stress axis decreased. In brown adipose tissue (BAT), IBF-R administration increased mitochondrial biogenesis and thermogenesis markers like PGC1α and UCP1 via AMPK-SIRT1 signaling and mTOR-SREBP1-ER stress-mitochondrial function axis. Moreover, IBF-R influenced the recovery of PGC1α deacetylation via SIRT1 activation. These observations suggest that IBF-R protects against obesity by playing multiple modulatory roles in liver steatosis, adipocyte metabolism, and BAT function mediated by AMPK-SIRT1 axis and ROS regulating pathways.

【 授权许可】

Unknown