Long COVID Neuropsychological Deficits after Severe, Moderate, or Mild Infection

Clinical and Translational Neuroscience

Philippe Voruz¹  Jordan Pierce¹  Anthony Nuber-Champier¹  Isabele Jacot de Alcântara¹  Julie A. Péron¹  Marine Thomasson¹  Olivia Braillard²  Jérôme Pugin³  Idris Guessous³  Jacques Serratrice³  Basile N. Landis³  Radek Ptak³  Lamyae Benzakour³  Karl-Olof Lövblad³  Matteo Coen³  Gilles Allali⁴  Frédéric Assal⁴  Patrice H. Lalive⁴ 

[1] Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, 1205 Geneva, Switzerland;Division and Department of Primary Care, Geneva University Hospitals, 1205 Geneva, Switzerland;Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland;Neurology Department, Geneva University Hospitals, 1205 Geneva, Switzerland;

关键词: cognitive deficits;    neuropsychology;    psychiatric symptoms;    long COVID;    SARS-CoV-2;   

DOI  :  10.3390/ctn6020009

来源: DOAJ

【 摘 要 】

There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, even in its mild or moderate respiratory forms, can include long-term neuropsychological deficits. Standardized neuropsychological, psychiatric, neurological, and olfactory tests were administered to 45 patients 236.51 ± 22.54 days after hospital discharge following severe, moderate, or mild respiratory severity from SARS-CoV-2 infection (severe = intensive care unit hospitalization, moderate = conventional hospitalization, mild = no hospitalization). Deficits were found in all domains of cognition, and the prevalence of psychiatric symptoms was relatively high in the three groups. The severe infection group performed more poorly on long-term episodic memory tests and exhibited greater anosognosia than did the other two groups. Those with moderate infection had poorer emotion recognition, which was positively correlated with persistent olfactory dysfunction. Individuals with mild infection were more stressed, anxious, and depressed. The data support the hypothesis that the virus targets the central nervous system (notably the limbic system) and the notion that there are different neuropsychological phenotypes.

【 授权许可】

Unknown