Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling

International Journal of Molecular Sciences

Monica Ragusa¹  Micaela Gliozzi²  Vincenzo Musolino²  Antonio Cardamone²  Rocco Mollace²  AnnaRita Coppoletta²  Ernesto Palma²  MariaCaterina Zito²  Roberta Macrì²  Saverio Nucera²  Francesca Bosco²  Vincenzo Mollace²  Stefano Ruga²  Lorenza Guarnieri²  Federica Scarano²  Cristina Carresi²  Irene Bava²  Miriam Scicchitano²  Jessica Maiuolo² 

[1] Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy;Department of Health Sciences, Institute of Research for Food Safety & Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy;

关键词: metabolic diseases;    obesity;    inflammation;    WAT;    BAT;    browning;   

DOI  :  10.3390/ijms22073351

来源: DOAJ

【 摘 要 】

The high incidence of obesity is associated with an increasing risk of several chronic diseases such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Sustained obesity is characterized by a chronic and unsolved inflammation of adipose tissue, which leads to a greater expression of proinflammatory adipokines, excessive lipid storage and adipogenesis. The purpose of this review is to clarify how inflammatory mediators act during adipose tissue dysfunction in the development of insulin resistance and all obesity-associated diseases. In particular, we focused our attention on the role of inflammatory signaling in brown adipose tissue (BAT) thermogenic activity and the browning of white adipose tissue (WAT), which represent a relevant component of adipose alterations during obesity. Furthermore, we reported the most recent evidence in the literature on nutraceutical supplementation in the management of the adipose inflammatory state, and in particular on their potential effect on common inflammatory mediators and pathways, responsible for WAT and BAT dysfunction. Although further research is needed to demonstrate that targeting pro-inflammatory mediators improves adipose tissue dysfunction and activates thermogenesis in BAT and WAT browning during obesity, polyphenols supplementation could represent an innovative therapeutic strategy to prevent progression of obesity and obesity-related metabolic diseases.

【 授权许可】

Unknown