Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS−CoV−2 Infection: An In−Silico Investigation

International Journal of Molecular Sciences

Pablo Luis Baia Figueiredo¹  Kendall G. Byler²  William N. Setzer³  Joyce Kelly R. da Silva⁴ 

[1] Departamento de Ciências Naturais, Centro de Ciências Sociais e Educação, Universidade do Estado do Pará, Belém, PA 66050−540, Brazil;Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA;Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA;Laboratório de Biotecnologia de Enzimas e Biotransformações, Universidade Federal do Pará, Belém, PA 66075−900, Brazil;

关键词: COVID−19;    corona virus;    molecular docking;    antiviral;    essential oils;   

DOI  :  10.3390/ijms21103426

来源: DOAJ

【 摘 要 】

Essential oils have shown promise as antiviral agents against several pathogenic viruses. In this work we hypothesized that essential oil components may interact with key protein targets of the 2019 severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2). A molecular docking analysis was carried out using 171 essential oil components with SARS−CoV−2 main protease (SARS−CoV−2 M^pro), SARS−CoV−2 endoribonucleoase (SARS−CoV−2 Nsp15/NendoU), SARS−CoV−2 ADP−ribose−1″−phosphatase (SARS−CoV−2 ADRP), SARS−CoV−2 RNA−dependent RNA polymerase (SARS−CoV−2 RdRp), the binding domain of the SARS−CoV−2 spike protein (SARS−CoV−2 rS), and human angiotensin−converting enzyme (hACE2). The compound with the best normalized docking score to SARS−CoV−2 M^pro was the sesquiterpene hydrocarbon (E)−β−farnesene. The best docking ligands for SARS−CoV Nsp15/NendoU were (E,E)−α−farnesene, (E)−β−farnesene, and (E,E)−farnesol. (E,E)−Farnesol showed the most exothermic docking to SARS−CoV−2 ADRP. Unfortunately, the docking energies of (E,E)−α−farnesene, (E)−β−farnesene, and (E,E)−farnesol with SARS−CoV−2 targets were relatively weak compared to docking energies with other proteins and are, therefore, unlikely to interact with the virus targets. However, essential oil components may act synergistically, essential oils may potentiate other antiviral agents, or they may provide some relief of COVID−19 symptoms.

【 授权许可】

Unknown