Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features

Cancer Medicine

Paolo Chieffi¹  Andrea Ronchi²  Immacolata Cozzolino²  Federica Zito Marino²  Marina Accardo²  Iacopo Panarese²  Renato Franco²  Marco Montella²  Sabrina Rossetti³  Gaetano Facchini³ 

[1] Department of Psychology University of Campania “L. Vanvitelli” Caserta Italy;Pathology Unit Department of Mental and Physical Health and Preventive Medicine University of Campania “L. Vanvitelli” Naples Italy;Uro‐Andrologic Oncology Unit Department of Uro‐Gynaecological Oncology Istituto Nazionale Tumori “Fondazione G. Pascale”—IRCCS Naples Italy;

关键词: choriocarcinoma;    chromosome 12p;    embryonal carcinoma;    extragonadal germ cell tumors;    SALL4;    seminoma;   

DOI  :  10.1002/cam4.2195

来源: DOAJ

【 摘 要 】

Abstract Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.

【 授权许可】

Unknown