Assessing public perception of a sand fly biting study on the pathway to a controlled human infection model for cutaneous leishmaniasis

Research Involvement and Engagement

Morgan Steigmann¹  Georgina Jones²  Nina Martin²  Paul Kaye³  Charles J. Lacey³  Vivak Parkash³  Alison M. Layton³  Elizabeth Greensted³ 

[1] Public involvement group participant;School of Social Sciences, Leeds Beckett University;York Biomedical Research Institute, Hull York Medical School, University of York;

关键词: Controlled human infection model (CHIM);    human challenge;    Cutaneous leishmaniasis;    Leishmania;    Clinical study;    Public involvement;   

DOI  :  10.1186/s40900-021-00277-y

来源: DOAJ

【 摘 要 】

Plain English summary Our research team is designing a type of research study known as a controlled human infection model (CHIM). In CHIM studies, volunteers are exposed to infections on purpose and then studied to help understand diseases. Similar experiments, where humans are infected deliberately, have been used for hundreds of years to help test treatments. CHIM studies have already been used more recently to help test vaccines for diseases such as malaria. The disease leishmaniasis, a disease affecting millions each year, is spread by the bite of an infected sand fly in tropical countries. There are currently no vaccines for leishmaniasis that are available for use in humans. It is thought that by using CHIM studies, new vaccines might be tested and then approved more quickly. Scientific researchers have had many discussions about how useful CHIM studies are, especially in terms of the science behind them, the safety of volunteers and the ethics of these studies. Researchers also understand how important it is to involve the public in designing and carrying out research, especially studies involving humans, to get an independent point-of-view. We have therefore involved the public, in some parts of designing this research, in a group discussion. We also included a person who has already taken part in a different CHIM study. These discussions have had an important effect and have changed how we plan to carry out our future research studies. We also hope that this description will encourage other researchers to include the public when planning future research.

【 授权许可】

Unknown