Under Pressure: Mechanical Stress Management in the Nucleus

Cells

Néjma Belaadi¹  Julien Aureille²  Christophe Guilluy² 

[1] Institut National de la Santé et de la Recherche Médicale, UMR 1087, l’institut du thorax, CNRS, UMR 6291, Université de Nantes, 44000 Nantes, France;Institut National de la Santé et de la Recherche Médicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Université Grenoble Alpes, 38041 Grenoble, France;

关键词: mechanotransduction;    nucleoskeleton;    lamina;    lamin;    LINC;    nucleus;    mechanical stress;   

DOI  :  10.3390/cells5020027

来源: DOAJ

【 摘 要 】

Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.

【 授权许可】

Unknown