Lamins, laminopathies and disease mechanisms: Possible role for proteasomal degradation of key regulatory proteins

Journal of biosciences

Veena K Parnaik1¹  B H Muralikrishna¹  Pankaj Chaturvedi¹ 

[1] Centre for Cellular and Molecular Biology (CSIR), Hyderabad 500 007, India$$

关键词: DNA repair;    heterochromatin;    lamin;    nuclear envelope;    proteasome;    ubiquitin ligases;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.

【 授权许可】

Unknown