SPIONs as a nanomagnetic catalyst for the synthesis and anti-microbial activity of 2-aminothiazoles derivatives

Arabian Journal of Chemistry

Haya A. Abubshait¹  Fadilah Sfouq Aleanizy¹  Sara Nabil²  Asma M. Elsharif³  Hamad M. Alkahtani⁴  M. Nasiruzzaman Shaikh⁴  Samar A. Abubshait⁴ 

[1] Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia;Corresponding author.;Basic Sciences Department, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia;Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia;

关键词: Nanomagnetic catalysis;    2-aminothiazole derivatives;    Pyrazolyl derivatives;    Schiff bases;    Aromatic aldehyde;    Anti-microbial activity;   

DOI  :  

来源: DOAJ

【 摘 要 】

A series of aminothiazole derivatives have been synthesized by using ultrasmall superparamagnetic iron oxide nanoparticles (SPIONs) nanomagnetic catalysis, which were prepared by reducing the Fe(II) and Fe(III) precursors using aqueous ammonia then characterized by the XRD, FTIR, SEM, and TEM. The 2-aminothiazole derivatives were obtained by coupling 2-aminothiazole diazonium salt with active methylene compounds then cyclization with hydrazine hydrate to afford pyrazolyl derivatives. The one-pot reaction of 2-aminothiazole with an aromatic aldehydes in the presence of Fe3O4 NPs to give Schiff bases derivatives. An efficient protocol is developed proudest yields and reduction reaction time and easy separation. Therefore, all synthesized compounds were evaluated for anti-microbial activity.

【 授权许可】

Unknown