Synthesis, Characterization and Antimicrobial Evaluation of Some New Schiff, Mannich and Acetylenic Mannich Bases Incorporating a 1,2,4-Triazole Nucleus

Molecules

Mohamed R. Aouad¹ 

[1] Department of Chemistry, Faculty of Sciences, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia; E-Mail:

关键词: Schiff bases;    Mannich bases;    acetylenic Mannich bases;    1;    2;    4-triazole;    antimicrobial activity;   

DOI  :  10.3390/molecules191118897

来源: mdpi

【 摘 要 】

A series of Schiff and Mannich bases derived from 4-amino-5-(3-fluoro-phenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione were synthesized. The alkylation of 4-phenyl-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione with propargyl bromide afforded the corresponding thiopropargylated derivative which upon treatment with the appropriate secondary amines in the presence of CuCl₂ furnished the desired acetylenic Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, ¹H- and ¹³C-NMR) data and evaluated for their biological activities. Some of the compounds were found to exhibit significant antimicrobial activity.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.