Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome[S]

Journal of Lipid Research

Adi L. Tarca¹  Zhonghui Xu²  Sen-Lin Zhou³  Ricardo Gomez⁴  Kenneth V. Honn⁴  Roberto Romero⁵  Tinnakorn Chaiworapongsa⁶  Krishna Rao Maddipati⁷  Piya Chaemsaithong⁸  Nikolina Docheva⁸  Juan Pedro Kusanovic⁸ 

[1] Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI;Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI;Lipidomics Core Facility, Wayne State University School of Medicine, Detroit, MI;To whom correspondence should be addressed;Bioactive Lipids Research Program, Department of Pathology, Wayne State University School of Medicine, Detroit, MI;Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI;

关键词: lipoxygenase;    eicosanoids;    inflammation;    omega-3 fatty acids;    lipidomics;    intra-amniotic inflammation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Clinical chorioamnionitis at term (TCC) is the most common obstetrical infliction diagnosed in labor and delivery units worldwide and is associated with a substantial increase in maternal and neonatal morbidity and mortality. This obstetrical complication is a heterogeneous condition, as only half of patients have detectable microorganisms in the amniotic cavity. Because bioactive lipids play a key role in the initiation and resolution of an inflammatory response, we aimed to characterize the amniotic fluid lipidome in patients with TCC. We studied the amniotic fluid of patients in the following groups: 1) spontaneous labor at term without clinical chorioamnionitis (TLB) and 2) spontaneous labor at term with clinical chorioamnionitis (TCC). The TCC group was subdivided into a) those with microbial invasion of the amniotic cavity (TCC-MIAC) and b) those without microbial invasion of the amniotic cavity (TCC-noMIAC). The amniotic fluid concentration of proinflammatory lipid mediators did not differ between patients in TLB with TCC. In contrast, concentration of lipids with anti-inflammatory/proresolution properties was significantly lower in all patients with TCC than in those with TLB. These results suggest that while proinflammatory lipid mediators are involved in infection-driven intra-amniotic inflammation, a relative deficiency of anti-inflammatory/proresolution lipid mediator biosynthesis is a characteristic of TCC.

【 授权许可】

Unknown