Bioactive Compounds from the Stems of Clausena lansium

Molecules

Li Li¹  Hua Sun¹  Nai-Hong Chen¹  Dong-Ming Zhang¹  Yi-Qian Du¹  Jie Liu¹  Chuang-Jun Li¹ 

[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

关键词: Clausena lansium;    phenolic glycosides;    terpenoids;    neuroprotective activities;    hepatoprotective activities;   

DOI  :  10.3390/molecules22122226

来源: DOAJ

【 摘 要 】

In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the stems of C. lansium in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A–B (1–2), one new pair of phenolic enantiomers (3a, 3b), and two new monoterpenoids, clausenapene A–B (4–5), together with twelve known analogues (6–17) were isolated from the stems of C. lansium. Compounds 1–17 were obtained from C. lansium for the first time. Compounds 3a, 3b, 4, 16, and 17 showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury induced by okadaic acid, and compound 9 exhibited strong potential hepatoprotective activities. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, NMR experiments, and electronic circular dichroism (ECD) spectra.

【 授权许可】

Unknown