CircRNAs in cancer metabolism: a review

Journal of Hematology & Oncology

Na Fang¹  Yu Fan¹  Tongshan Wang²  Tao Yu²  Yongqian Shu²  Tongpeng Xu²  Yanfen Wang³ 

[1] Cancer Institute, The Affiliated People’s Hospital of Jiangsu University;Department of Oncology, First Affiliated Hospital of Nanjing Medical University;Department of Pathology, The Affiliated Hospital of Yangzhou University;

关键词: Cancer metabolism;    CircRNAs;    Warburg effect;    Lipid metabolism;    Glutamine;    ROS;   

DOI  :  10.1186/s13045-019-0776-8

来源: DOAJ

【 摘 要 】

Abstract Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid and amino acid are orchestrated not only by carcinogenic proteins but by non-coding RNAs. Among them, circular RNA (circRNA), as a kind of novel identified non-coding RNAs, has become the focus of attention. Through binding with corresponding microRNAs or directly contacting proteins, circRNA plays a primarily important role in regulating cellular metabolism. Herein, we analyze the emerging findings and select circRNAs contributing to mutant glycolysis, lipogenesis and lipolysis, glutam inolysis, and oxidative respiration to deepen the understanding about the cancer metabolic regulatory network. In addition, we also discuss the possibility of circRNAs exerting their functions via exosomes and cancer stem cells. Owing to their unique structures and wide impacts, circRNAs may help reap huge fruits in developing clinical treatments targeting cancer metabolism.

【 授权许可】

Unknown