Cancer Metabolism: What we Can Learn from Proteomic Analysis by Mass Spectrometry

Cancer Genomics - Proteomics

Weidong Zhou¹  Lance A. Liotta¹  Emanuel F. Petricoin¹ 

[1] Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, U.S.A.Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, U.S.A.Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, U.S.A.

关键词: Cancer metabolism;    Warburg effect;    oxidative stress;    mass spectrometry;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

A variety of genomic and proteomic tools have been used to study cancer metabolism and metabolomics in order to understand how cancer cells survive in their environment. Throughout the past decade, mass spectrometry has been routinely used for large-scale protein identification of complex biological mixtures. In this review, we discuss some recent developments in cancer metabolism by proteomic analysis using mass spectrometric techniques, focusing on pyruvate kinase, L-lactate dehydrogenase, Warburg effect, glutamine metabolism and oxidative stress.

【 授权许可】

Unknown