Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

Frontiers in Immunology

Ashish Rai¹  Eric Abston²  Duo Zhang²  Heedoo Lee²  Yang Jin² 

[1] Department of Internal Medicine, North Shore Medical Center, Boston, MA, United States;Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, MA, United States;

关键词: macrophage-epithelium crosstalk;    lung injury and inflammation;    extracellular vesicles;    exosome;    microvesicle;    apoptosis;   

DOI  :  10.3389/fimmu.2018.00924

来源: DOAJ

【 摘 要 】

Inflammatory lung responses are one of the characterized features in the pathogenesis of many lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Alveolar macrophages (AMs) and alveolar epithelial cells are the first line of host defense and innate immunity. Due to their central roles in both the initiation and resolution of inflammatory lung responses, AMs constantly communicate with other lung cells, including the alveolar epithelial cells. In the past, emerging evidence suggests that extracellular vesicles play an essential role in cell–cell crosstalk. In this review, we will discuss the recent findings on the intercellular communications between lung epithelial cells and alveolar macrophages, via EV-mediated signal transfer.

【 授权许可】

Unknown