PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

Molecules

Robin L. Jones¹  Bradley J. Petek² 

[1] Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East,G-3630, Seattle, WA 98109-1023, USA;University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA;

关键词: PM00104;    Zalypsis;    alkaloid;    chemotherapy;    cancer therapy;   

DOI  :  10.3390/molecules190812328

来源: DOAJ

【 摘 要 】

PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, whichis structurally similar to many marine organisms. The compound has been proposedas a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.

【 授权许可】

Unknown