PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

Molecules

Bradley J. Petek¹ 

[1] University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA; E-Mail:

关键词: PM00104;    Zalypsis;    alkaloid;    chemotherapy;    cancer therapy;   

DOI  :  10.3390/molecules190812328

来源: mdpi

【 摘 要 】

PM00104 (Zalypsis^®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.