Proton beam therapy for a giant hepatic hemangioma: A case report and literature review

Clinical and Translational Radiation Oncology

Toshiyuki Okumura¹  Keiichirou Baba²  Masashi Mizumoto³  Shosei Shimizu³  Motohiro Murakami³  Yinuo Li³  Kei Nakai³  Toshiki Ishida³  Haruko Numajiri³  Takashi Iizumi³  Yuichi Hiroshima³  Masatoshi Nakamura³  Masaharu Hata³  Takashi Saito³  Hideyuki Sakurai⁴ 

[1] Corresponding author at: Department of Radiation Oncology, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.;Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan;Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan;Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan;

关键词: Radiotherapy;    Proton beam therapy;    Hemangioma;    Liver;    Secondary cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Hepatic hemangiomas are benign tumors with a favorable prognosis, but giant hepatic hemangiomas can cause abdominal symptoms and are indicated for treatment. Most cases are treated with surgery, but radiotherapy has also been used. However, to date, there have been no reports of proton beam therapy for a hepatic hemangioma. Case presentation: A 46-year-old woman had a tumor of 80 × 80 mm in the left medial lobe of the liver, which was diagnosed as a giant hemangioma based on the contrast pattern. Therapy was required for a giant hepatic hemangioma with symptoms, but the patient refused blood transfusion due to religious reasons, which made surgical resection difficult. Therefore, she was referred to our hospital for proton beam therapy. At her first visit, liver function was Child-Pugh A (5 points) and there was no elevation of tumor markers. Proton beam therapy of 28.6 Gy (RBE) given in 13 fractions was performed without interruption. The only observed acute radiation toxicity was Grade 1 dermatitis. One year after proton beam therapy, the hemangioma had significantly decreased, and a complete response has been maintained for 15 years based on ultrasound and MRI. Conclusion: This case is the first reported use of proton beam therapy for a hepatic hemangioma. The outcome suggests that this treatment may be effective for a giant liver hemangioma.

【 授权许可】

Unknown