Study on the effect of different types of sugar on lipid deposition in goose fatty liver

Poultry Science

Shouhai Wei¹  Xianyin Zeng¹  Cangcang Lu²  Jiwei Hu²  Rongxue Wei²  Hongyong Xu²  Mariama Abdulai²  Chunchun Han²  Hehe Liu²  Shenqiang Hu²  Liang Li²  Donghang Deng²  Yongqiang Teng²  Zhaoyun Luo² 

[1] College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, P.R. China;Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, P.R. China;

关键词: goose fatty liver;    glucose;    fructose;    sucrose;    lipid deposition;   

DOI  :  

来源: DOAJ

【 摘 要 】

ABSTRACT: Early research in our lab indicated that the effect of glucose, fructose and sucrose on the levels of triacylglycerol, and inflammatory factor was significantly different, and it is speculated that the regulatory mechanism of lipid deposition by different type of sugar in the liver is different. In order to explore lipid deposition difference mediated by different types of sugar (glucose, fructose, and sucrose) in goose fatty liver formation, this experiment was performed from cell culture, overfeeding experiment, and transcriptome analysis at 3 levels. Cell culture experiment results indicated that the levels of intracellular triglyceride, total cholesterol, and lipid content of fructose and sucrose treatment were significantly higher than those of glucose treatment (P < 0.05). In slaughter performance, the liver weight, the ratio of liver weight to body weight, feed conversion ratio (liver weight/feed consumption) were better in sucrose overfeeding group (P < 0.05). In addition, the liver of the sucrose overfeeding group contained a lot of unsaturated fatty acids, especially (n-3) polyunsaturated fatty acids (P < 0.05). Transcriptome analysis shown that the peroxisome proliferators-activated receptor (PPAR) signaling pathway is highly enriched in the fructose and sucrose overfeeding groups; cell cycle, and DNA replication pathways were highly enriched in the glucose overfeeding group. In conclusion, due to the decrease of lipids outward transportation and the anti-inflammation of unsaturated fatty acids, fructose, and sucrose have better ability to induce steatosis in goose fatty liver formation.

【 授权许可】

Unknown