A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Health Science Reports

Mohammad Hossein Mohammadi¹  Vahid Amiri¹  Mohammad Rafiee¹  Mohieddin Barzegar¹  Mohammad Abbasi²  Hassan Rafieemehr³  Amin Mirzaeian⁴  Shaghayegh Shahsavan⁵ 

[1] Department of Hematology and Blood Banking School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences Tehran Iran;Department of Internal Medicine Hamadan University of Medical Sciences Hamadan Iran;Department of Medical Laboratory Sciences School of Paramedicine, Hamadan University of Medical Sciences Hamadan Iran;Hematopoietic Stem Cells Transplantation Research Center, Laboratory and Blood Banking Department, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences Tehran Iran;Stem Cell Transplantation and Cell Therapy Center Taleghani Hospital Tehran Iran;

关键词: engraftment;    graft vs host disease;    hematopoietic stem cell transplantation;    outcomes;    relapse;    survival;   

DOI  :  10.1002/hsr2.282

来源: DOAJ

【 摘 要 】

Abstract Background and aims As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non‐hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes. Methods We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included. Results Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed. Conclusion The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.

【 授权许可】

Unknown