Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019

Nutrients

Camille Baudry¹  Lucie Allard¹  Julie Molleville¹  Helene Bihan¹  Emmanuel Cosson¹  David Deutsch²  Olivier Bouchaud³  Elise Ouedraogo³  Bénédicte Giroux-Leprieur⁴  Morgane Didier⁵  Angela Sutton⁶  Constant Josse⁷ 

[1] Department of Endocrinology-Diabetology-Nutrition, AP-HP Avicenne Hospital, 93000 Bobigny, France;Department of Gastroenterology and Digestive Oncology, AP-HP Avicenne Hospital, 93000 Bobigny, France;Department of Infectious Disease, AP-HP Avicenne Hospital, 93000 Bobigny, France;Department of Internal Medicine, AP-HP Avicenne Hospital, 93000 Bobigny, France;Department of Respiratory Disease, AP-HP Avicenne Hospital, 93000 Bobigny, France;Laboratory for Vascular Translational Science (LVTS), Inserm U1148 Groupe Biothérapies et Glycoconjugués/Université Paris 13—Sorbonne Paris Nord, 93000 Bobigny, France;eXYSTAT, 92240 Malakoff, France;

关键词: malnutrition;    nutritional risk;    COVID-19;    prognosis;   

DOI  :  10.3390/nu12123679

来源: DOAJ

【 摘 要 】

Previous studies have found a correlation between malnutrition and prognosis in respiratory infections. Our objectives were to determine (i) the percentage of malnutrition, and (ii) its prognosis in patients admitted for coronavirus disease 2019 (COVID-19). In this monocentric retrospective study, we consecutively included all adult patients presenting with acute COVID-19 between 9 April and 29 May 2020. Malnutrition was diagnosed on low body mass index (BMI) and weight loss ≥ 5% in the previous month and/or ≥ 10% in the previous six months. The Nutritional Risk Index (NRI) defined nutritional risk. Severe COVID-19 was defined as a need for nasal oxygen ≥ 6 L/min. We enrolled 108 patients (64 men, 62 ± 16 years, BMI 28.8 ± 6.2 kg/m²), including 34 (31.5%) with severe COVID-19. Malnutrition was found in 42 (38.9%) patients, and moderate or severe nutritional risk in 83 (84.7%) patients. Malnutrition was not associated with COVID-19 severity. Nutritional risk was associated with severe COVID-19 (p < 0.01; p < 0.01 after adjustment for C reactive protein), as were lower plasma proteins, albumin, prealbumin, and zinc levels (p < 0.01). The main cause of malnutrition was inflammation. The high percentage of malnutrition and the association between nutritional risk and COVID-19 prognosis supports international guidelines advising regular screening and nutritional support when necessary.

【 授权许可】

Unknown