期刊论文详细信息
Life
Microvascular and Morphologic Changes of the Macula over Lifetime
Moritz Glaser1  Claudia Lommatzsch1  Mael Lever2  Michael R. R. Böhm2  Ying Chen2  Nikolaos E. Bechrakis2  Jan Darius Unterlauft3 
[1] Achim Wessing Institute for Imaging in Ophthalmology, University Hospital Essen, 45147 Essen, Germany;Department of Ophthalmology, University Hospital Essen, 45147 Essen, Germany;Department of Ophthalmology, University Hospital of Ophthalmology, Inselspital, 3010 Bern, Switzerland;
关键词: macula;    macular segmentation;    aging;    optical coherence tomography-angiography;    vascular disease;    capillary density;   
DOI  :  10.3390/life12040568
来源: DOAJ
【 摘 要 】

In ocular, neurologic, and cardiovascular diseases, macular segmentation data from spectral-domain optical coherence tomography (SD-OCT) provide morphologic, and OCT-angiography (OCTA) results give microvascular information about the macula. Age was shown to influence both methods’ measurements. To further characterize this association, macular SD-OCT and OCTA changes were investigated in a population of juvenile, adult, and older individuals. Macular segment thickness and superficial (SCP) and deep plexus (DCP) vascular density (VD) of 157 healthy individuals aged 10–79 years were analyzed retrospectively. One-way analysis of variance (ANOVA) was used to compare age groups. The association between macular segmentation and OCTA parameters and between these and age was evaluated using linear regression. ANOVA and linear regression analysis showed a thickness decrease in the whole macular and in the ganglion cell and inner plexiform layers with age. While the foveal avascular zone area remained constant between age groups, VD of the SCP and DCP also decreased with age. In multiple linear regression, SCP and DCP VD were associated with inner macular segment thickness in an age-independent way. To conclude, the age-related microvascular and morphological changes in the macula described in this study can contribute to improving the understanding of macular aging processes and better interpreting OCT(A) results in healthy individuals and patients suffering from various retinal diseases.

【 授权许可】

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