Physiological significance of Fuc and Sialic acid containing glycans in the body

Arabian Journal of Chemistry

Abdul Razaq¹  Mukhtarul Hassan¹  Zeeshan Iqbal²  Nasirud Din²  Muhammad Ramzan Manwar Hussain² 

[1] Institute of Chemistry, University of the Punjab, Lahore, Pakistan;Institute of Molecular Sciences and Bioinformatics, Lahore, Pakistan;

关键词: Complex carbohydrates;    Fucose;    Sialic acid;    Stereochemical features;    Cellular physiology;   

DOI  :  10.1016/j.arabjc.2011.06.028

来源: DOAJ

【 摘 要 】

Complex biomolecular machinery carrying diverse glycan chains are involved in a wide range of physiological activities including blood group determination, cancer recognition protein stabilization and sperm–egg interaction. Diversity of glycan chains, linked to lipids and proteins is due to isomeric and conformational modifications of various sugar residues, giving rise to unique carbohydrate structures with a wide range of anomeric linkages. This unique and significant structural diversity of naturally occurring oligosaccharide structures make them the best recognition markers for countless physiological activities. This is a challenging task to explore the relationship between biological processes and stereochemical behavior of sugar residues. Current review article is related with the physiological significance of glycans carrying fucose and/or sialic residues in complex biomolecular assemblies. Both the sugar units have a diverse range of anomery and linkages with the penultimate sugars. The existing literature and databases did not contain comprehensive information regarding structure–function relationship of glycans. Therefore, the current study is scheduled to debate on the structure–function relationship of glycans carrying Fuc and sialic acid in their backbone structures.

【 授权许可】

Unknown