Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease

Frontiers in Cell and Developmental Biology

Haixia Zhuang¹  Du Feng¹  Hao Liu¹  Xiao Liu²  Jinbao Liu³  Yiming Xu⁴  Pengcheng He⁵  Hualin Fan⁶  Dongxing Zhu⁶ 

[1] Institute of Guangzhou Medical University, Guangzhou, China;;Affiliated Cancer Hospital &Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;Guangdong Provincial People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China;Guangzhou Institute of Cardiovascular Diseases, The Second Affiliated Hospital, Key Laboratory of Cardiovascular Diseases, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China;School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China;

关键词: mitochondrial-associated membranes;    mitochondria;    autophagy;    cardiovascular disease;    inflammation;    inflammasome;   

DOI  :  10.3389/fcell.2020.00692

来源: DOAJ

【 摘 要 】

The mitochondrion, the ATP-producing center, is both physically and functionally associated with almost all other organelles in the cell. Mitochondrial-associated membranes (MAMs) are involved in a variety of biological processes, such as lipid exchange, protein transport, mitochondrial fission, mitophagy, and inflammation. Several inflammation-related diseases in the cardiovascular system involve several intracellular events including mitochondrial dysfunction as well as disruption of MAMs. Therefore, an in-depth exploration of the function of MAMs will be of great significance for us to understand the initiation, progression, and clinical complications of cardiovascular disease (CVD). In this review, we summarize the recent advances in our knowledge of MAM regulation and function in CVD-related cells. We discuss the potential roles of MAMs in activating inflammation to influence the development of CVD.

【 授权许可】

Unknown