Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency

Frontiers in Immunology

Claire Booth¹  Winnie Ip¹  Justin Penner²  Nuria Sanchez Clemente³  Judith Breuer⁴ 

[1] Inflammation Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom;Tropical Medicine, London, United Kingdom;;Department of Infectious Disease Epidemiology, London School of Hygiene &Immunology and Infectious Diseases Department, Great Ormond Street Hospital for Children, London, United Kingdom;;Infection, Immunity &

关键词: primary immunodeficiency;    APDS2;    SARS-CoV-2;    COVID-19;    case report;   

DOI  :  10.3389/fimmu.2022.881259

来源: DOAJ

【 摘 要 】

Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.

【 授权许可】

Unknown