Label-Free Monitoring of Diffusion in Microfluidics

Micromachines

Kristian Tølbøl Sørensen¹  Anders Kristensen¹ 

[1] Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby 2800, Denmark;

关键词: optofluidics;    microfluidics;    diffusion;    convection;    mixing;    refractive index;    label-free;   

DOI  :  10.3390/mi8110329

来源: DOAJ

【 摘 要 】

Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).

【 授权许可】

Unknown