Review of Microfluidic Photobioreactor Technology for Metabolic Engineering and Synthetic Biology of Cyanobacteria and Microalgae

Micromachines

Ya-Tang Yang¹  Chun Ying Wang¹ 

[1] Department of Electrical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan;

关键词: cyanobacteria;    photobioreactor;    photosynthesis;    synthetic biology;    metabolic engineering;    microfluidics;    optofluidics;    photobiology;    bioreactor;   

DOI  :  10.3390/mi7100185

来源: DOAJ

【 摘 要 】

One goal of metabolic engineering and synthetic biology for cyanobacteria and microalgae is to engineer strains that can optimally produce biofuels and commodity chemicals. However, the current workflow is slow and labor intensive with respect to assembly of genetic parts and characterization of production yields because of the slow growth rates of these organisms. Here, we review recent progress in the microfluidic photobioreactors and identify opportunities and unmet needs in metabolic engineering and synthetic biology. Because of the unprecedented experimental resolution down to the single cell level, long-term real-time monitoring capability, and high throughput with low cost, microfluidic photobioreactor technology will be an indispensible tool to speed up the development process, advance fundamental knowledge, and realize the full potential of metabolic engineering and synthetic biology for cyanobacteria and microalgae.

【 授权许可】

Unknown