Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (S)-1-(3-Methoxyphenyl)ethylamine

Crystals

Erik Temmel¹  Janvon Langermann²  Peter Kumm²  Dennis Hülsewede² 

[1] Sulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, Switzerland;University of Rostock, Institute of Chemistry, Biocatalytic Synthesis Group, Albert-Einstein-Str. 3A, 18059 Rostock, Germany;

关键词: amine;    biocatalysis;    enzyme;    process intensification;    crystallization;    enantioselective;   

DOI  :  10.3390/cryst10050345

来源: DOAJ

【 摘 要 】

An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (S)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stage Alzheimer’s disease. The three-part vessel system developed for this purpose consists of a membrane reactor for the continuous synthesis of the product amine, a saturator vessel for the continuous supply of the amine donor isopropylammonium and the precipitating reagent 3,3-diphenylpropionate and a crystallizer in which the product amine can continuously precipitate as (S)-1-(3-methoxyphenyl)ethylammonium-3,3-diphenylpropionate.

【 授权许可】

Unknown