Crystals | |
Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (S)-1-(3-Methoxyphenyl)ethylamine | |
Erik Temmel1  Janvon Langermann2  Peter Kumm2  Dennis Hülsewede2  | |
[1] Sulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, Switzerland;University of Rostock, Institute of Chemistry, Biocatalytic Synthesis Group, Albert-Einstein-Str. 3A, 18059 Rostock, Germany; | |
关键词: amine; biocatalysis; enzyme; process intensification; crystallization; enantioselective; | |
DOI : 10.3390/cryst10050345 | |
来源: DOAJ |
【 摘 要 】
An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (S)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stage Alzheimer’s disease. The three-part vessel system developed for this purpose consists of a membrane reactor for the continuous synthesis of the product amine, a saturator vessel for the continuous supply of the amine donor isopropylammonium and the precipitating reagent 3,3-diphenylpropionate and a crystallizer in which the product amine can continuously precipitate as (S)-1-(3-methoxyphenyl)ethylammonium-3,3-diphenylpropionate.
【 授权许可】
Unknown