Determination of carbonyl compounds in tobacco products for oral use

Zhongguo Yancao Xuebao

BI Yanjiu¹  LIU Hong¹  QI Dawei¹ 

[1] Shanghai Tobacco Group CO., LTD;

关键词: Carbonyl compounds;    tobacco products for oral use;    O-(2;    3;    6-pentafluorobenzyl)-hydroxylamine hydrochloride;    Derivatization;    GC-MS;   

DOI  :  10.16472/j.chinatobacco.2016.394

来源: DOAJ

【 摘 要 】

A derivatization gas chromatography-mass spectrometry (GC/MS) method with o-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride (PFBHA) was developed for the determination of formaldehyde, acetaldehyde and crotonaldehyde in tobacco products for oral use. Sample was extracted with water and part of aqueous extract was derivatizated with PFBHA. The PFBHA derivatives of carbonyls were extracted with hexane and analyzed by gas chromatography-mass spectrometry. The limits of detection ranged from 0.001-0.010 μg/g, with recoveries ranged from 91.7% to 104.1%. Results showed good inter-day repeatability (RSD≤9.6%) and intra-day repeatability (RSD ≤5.3%). 35 main brand products sold in European and American markets were analyzed, formaldehyde (0.275-2.397 μg/g), acetaldehyde (0.383-8.010 μg/g) and crotonaldehyde (0.003-0.027 μg/g) were detected in all these tested products. This method was simple, accurate and suitable for the analysis of formaldehyde, acetaldehyde and crotonaldehyde in tobacco products for oral use.

【 授权许可】

Unknown