Chicoric acid encapsulated within ferritin inhibits tau phosphorylation by regulating AMPK and GluT1 signaling cascade

Journal of Functional Foods

Siyu Huang¹  Changwei Ma¹  Yumeng Wang²  Chenyan Lv³  Guanghua Zhao³  Zhaohui Hu⁴  Xueli Cao⁴ 

[1] College of Food Science and Nutritional Engineering, China Agricultural University, Beijing Key Laboratory of Functional Food from Plant Resources, Beijing 100083, China;Corresponding authors at: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100037, China (C. Lv).;Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100037, China;College of Food Science and Nutritional Engineering, China Agricultural University, Beijing Key Laboratory of Functional Food from Plant Resources, Beijing 100083, China;

关键词: Ferritin;    Encapsulation;    Chicoric acid;    Penetration;    Tau phosphorylation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hyperphophorylation of tau protein is typical pathological features of Alzheimer's disease. Chicoric acid (CA) has been reported to inhibit formation of β amyloid peptide, it's hard to transport through blood brain barrier (BBB) and its role in inhibiting tau phosphorylation is unknown. In this study, we employed ferritin as a nanocage to encapsulate CA (Ft-CA), and stability, cell survival and BBB permeability of CA were improved by ferritin encapsulation, suggesting ferritin to be an effective vector for bioactive molecules. Meanwhile, both CA and Ft-CA were proved to inhibit tau phosphorylation in SH-SY5Y cells, and effects of Ft-CA are more obvious than CA. Roles of CA were proposed to regulate glucose metabolism by increasing GluT1 and promote glycosylation of tau protein. Meanwhile, CA was proved to inhibit phosphorylation of AMPK, which may further inhibit tau phosphorylation. These findings may provide a novel strategy to prevent neurodegenerative diseases by using dietary polyphenols.

【 授权许可】

Unknown