Telbivudine treatment started in early and middle pregnancy completely blocks HBV vertical transmission

BMC Gastroenterology

Shangfei Zhao¹  Mingquan Song¹  Lin Zhou²  Weihui Sun²  Anhua Hao²  Fengzhu Li²  Lei Ma²  Bo Zhao² 

[1] Department of Gastroenterology, The Affiliated Hospital of Qingdao University;Department of Hepatology, Chengyang People’s Hospital of Qingdao;

关键词: Telbivudine;    Hepatitis B virus;    Mother-to-infant transmission;    Fetus safety;    Drug efficacy;   

DOI  :  10.1186/s12876-017-0608-7

来源: DOAJ

【 摘 要 】

Abstract Background To evaluate the efficacy and safety of treating HBV-positive mothers with telbivudine in early and middle pregnancy to prevent mother-to-infant HBV transmission. Methods The subject population comprised pregnant women with chronic hepatitis B (CHB; n = 188) from January 2013 to June 2015, with HBV DNA ≥1.0 × 107copies/mL and increased alanine aminotransferase levels. Groups A (n = 62) and B (n = 61) were treated with telbivudine starting at 12 weeks or 20–28 weeks after gestation, respectively. Telbivudine was discontinued at postpartum 12 weeks. Group C (n = 65) received no antiviral. All infants were vaccinated with hepatitis B immunoglobulin (200 IU) and HBV vaccine (20 with hepatitis B The maternal HBV DNA levels of the groups were compared. Mother-to-infant transmission of HBV was indicated by the presence of HBsAg in infants 7 months after birth. Results Before treatment, the HBV DNA levels of the 3 groups were similar. Before delivery and 12 weeks after delivery, the HBV DNA levels of groups A and B were similar, but both were significantly lower than that of group C (P < 0.01, all). No infants in groups A and B were HBsAg-positive, but the infection rate of group C was 18.4% (P < 0.01). The HBV infection rate of infants was positively associated with the HBV DNA levels of the pregnant mothers. Conclusion Administration of telbivudine to HBV-infected mothers, started during early and middle pregnancy, completely blocked mother-to-infant HBV transmission. Trial registration The study was registered retrospectively on Janurary 25 in 2016 at Chinese Clinical Trial Registry ( ChiCTR-OPC-16007899 ).

【 授权许可】

Unknown